Phyllanthus niruri & Phyllanthus maderapatensis belongs to the family euphorbiaceae were screened to evaluate invitro antifungal activity against selected human pathogenic fungi which includes Trichophyton rubrum, Aspergillus niger, Candida albicans and Penicillium chrysogenum. The antifungal index of the ethanolic and n-hexane extracts with various concentration of selected plants were determined by agar diffusion method against test human fungal pathogens. With the increase in concentration of various extracts, antifungal activity also increased. An attempt has been made to compare the spectrum of inhibition of Phyllanthus species to that of standard antifungal drugs (clotrimaxazole and Nystatin). In addition , Phytochemical Screening of leaves, stem, root and seed extracts of the selected plants were also tested. The present investigation shows that antifungal activity of selected plants and the presence of potential bioactive components that may be of used for the development of phytomedicine for the therapy of tested fungal diseases. Further, from the present study the effective biomolecule which act as antifungal have to be identified, isolated and subjected to extensive scientific and pharmacological screening which led to be the source for new drugs. The activity can be increased further by genetic engineering methodology.
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